GH Secretagogues: CJC-1295 and Ipamorelin
The most widely used growth hormone-releasing peptide stack explained — how CJC-1295 and Ipamorelin work together to amplify the natural GH pulse.
GH AxisSermorelin: GHRH Analogue for Growth Hormone Stimulation
Sermorelin is a synthetic 29-amino acid GHRH analogue FDA-approved for growth hormone deficiency. Learn about its mechanism, dosing protocols, and clinical research.
GH AxisTesamorelin: Modified GHRH for Visceral Fat Reduction
Tesamorelin is an FDA-approved GHRH analogue modified with a trans-3-hexenoic acid moiety, proven to reduce HIV-associated lipodystrophy and visceral adiposity. Explore the mechanism and clinical evidence.
GH AxisGHRP-2: Potent Ghrelin Mimetic for GH Axis Stimulation
GHRP-2 is a potent growth hormone-releasing peptide that acts as a ghrelin receptor agonist, producing strong GH release but with elevated cortisol and prolactin. Learn about mechanism, stacking, and side effects.
GH AxisGHRP-6: Potent GH Secretagogue with Marked Appetite Stimulation
GHRP-6 is a hexapeptide ghrelin mimetic that powerfully stimulates growth hormone and appetite. Understand its mechanism, dosing, and why it's not combined with GHRP-2.
GH AxisCJC-1295 Without DAC: Pulsatile GH and Ipamorelin Synergy
CJC-1295 without DAC (Modified GRF 1-29) mimics native GHRH with a ~30-minute half-life, enabling synchronized GH pulses when stacked with Ipamorelin. Unlike its albumin-binding variant, this peptide preserves natural pulsatility—critical for sleep GH secretion and long-term GH axis health.
GH AxisCJC-1295 with DAC: Sustained GH Elevation and Albumin Binding Explained
CJC-1295 with DAC (Drug Affinity Complex) uses maleimidopropionic acid to bind serum albumin, extending half-life to 6-8 days and creating sustained GHRH agonism. This variant trades pulsatility for convenience and IGF-1 maximization—ideal for users prioritizing simplicity and long-term growth factor elevation over sleep GH preservation.